Homocysteine levels have been associated with coronary artery disease (CAD) however, after the Western Norway B-Vitamin Intervention Trial (WENBIT) failed to find protective effects of vitamin B supplementation especially with Folates and Vitamin B6, known to reduce homocysteine......the relationship remained just as it is "An Association", with no causal relationship between CAD and Homocysteine.
The Study included 3090 patients with established CAD randomized into vitamin B6 alone, Folic + Vitamin B12, Folic + Vit. B6 and B12 followed for 38months. Inspite of the lowering of folate by 28% in the folate group and unchanged in the non-folate group, there were no observed protective benefits in terms of reducing cardiac hard end points (MI, ACS and cardiac death)
This trial confirms the findings of similar trials in the past and may just be the last nail on the coffin regarding vitamin B supplementation as a secondary prevention for cardiac heart events.
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